Peer-reviewed veterinary case report
The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2021
- Authors:
- Sudo, Kasumi et al.
- Affiliation:
- National Veterinary Assay Laboratory · Japan
Abstract
We evaluated the role of classical swine fever virus (CSFV) in the formation of button ulcers in the mucosa of the gastrointestinal tract. Histopathological and immunohistochemical analyses of pigs experimentally infected with a subgenotype 2.1 isolate of CSFV, which was isolated in Japan in 2019, revealed follicular necrosis in the submucosal mucosa-associated lymphoid tissue and herniation of crypts as factors that contribute to the development of button ulcers during CSFV infection. These findings indicate that CSFV induces follicular necrosis and is one of the causative agents of button ulcers in pigs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33867396/