The Genetic Diversity and Interspecific Transmission of Circovirus inin Guangdong, Southern China.

Abstract

Circoviruses are a group of small circular, single-stranded DNA viruses that belong to the family. They are known to infect a wide variety of animals.is a species of rodent that is the reservoir of many zoonotic pathogens. Our previous study identified many sequencing reads mapped to the genome of viruses inin. However, little is known about the circulation and genetic characterization of circoviruses in. This study identified three different circoviruses in samples from 195. First, the bamboo rat circovirus is widely prevalent inin Guangdong Province, and all strains could be divided into three clades based on nucleotide substitutions at specific sites. Second, and more important, porcine circovirus 2 (PCV2) was isolated for the first time from, which expanded the host range of PCV2 and indicated extra procedures would be required to protect livestock from this virus. Finally, a novel circovirus phylogenetically close to the dromedary stool-associated circular ssDNA virus was detected in 86 (44.1%) samples, which may represent a new circovirus species. These results not only expand our understanding of the circovirus diversity in rodents, particularly in, but also underscore the importance of continued surveillance of viruses in wildlife populations, particularly in rodents, to prevent and control the spread of zoonotic pathogens.