Peer-reviewed veterinary case report
New histamine receptor target for treating dog skin allergies
By Rossbach, Kristine et al.·Published in Veterinary dermatology·2009·Department of Pharmacology, Germany·View original on PubMed →
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Original publication title: The histamine H receptor as a new target for treatment of canine inflammatory skin diseases.
- Species:
- dog
Plain-English summary
Twelve beagles were tested for allergic skin reactions by injecting histamine, which usually causes itching and redness. Interestingly, while the dogs showed a typical reaction with swelling, they did not scratch or show signs of itching. A specific treatment using a histamine H(4) receptor blocker helped reduce the swelling in most of the dogs. This suggests that targeting both H(1) and H(4) receptors might be a promising approach for treating skin allergies in dogs.
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Abstract
Histamine is a well known mediator of allergic skin diseases and, with the discovery of the histamine H(4) receptor, the role of histamine is re-evaluated. There are only limited published data elucidating the role of the histamine H(4) receptor in dogs. Twelve beagles intradermally injected with histamine (0.25 micromol and 2.5 micromol/site) reacted with a classical wheal and flare reaction. None of the dogs showed signs of pruritus. The dogs reacted with a wheal and flare reaction after intradermal injection of histamine H(4) receptor agonist/H(3) receptor antagonist clobenpropit (0.1 micromol) and selective histamine H(4) receptor agonist VUF 8430 (1.5 micromol). Again, no scratching occurred in any of the dogs. The highly selective histamine H(4) receptor antagonist JNJ 7777120 reduced the histamine-induced wheal reaction in nine out of 12 dogs. To determine whether canine mast cells are susceptible to histamine H(4) receptor-mediated reactions, effects of clobenpropit and VUF 8430 were tested in canine mastocytoma cells (C2). Incubation with histamine H(4) receptor agonists (up to 10 micromol/L) induced a distinct calcium(2+) influx. C2 cells also responded with enhanced chemotaxis when stimulated with histamine, VUF 8430 and clobenpropit. Neither VUF 8430, nor clobenpropit (up to 10 micromol/L) led to a modulation of histamine concentration in supernatants of canine mastocytoma cells, whereas mastoparan, used as a positive control, enhanced histamine concentration in supernatants. For treatment of allergic skin diseases in dogs, a combination of H(1)R and H(4)R antagonists might be advantageous.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20178494/