Peer-reviewed veterinary case report
Pigmentary and cystic glaucoma in Golden Retrievers explained
By Esson, Douglas et al.·Published in Veterinary ophthalmology·2009·Eye Care for Animals, United States·View original on PubMed →
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Original publication title: The histopathological and immunohistochemical characteristics of pigmentary and cystic glaucoma in the Golden Retriever.
- Species:
- dog
Plain-English summary
A group of Golden Retrievers with eye problems were found to have thin-walled cysts and pigment buildup in their eyes, which can lead to glaucoma (increased pressure in the eye). Researchers examined 15 affected eyes and discovered that all showed signs of cysts and pigment dispersion, but little inflammation. This suggests that the eye issues in these dogs might not be accurately described as uveitis (inflammation of the eye). Understanding these characteristics can help veterinarians better diagnose and treat glaucoma in Golden Retrievers.
People also search for: Golden Retriever eye problems · glaucoma treatment for dogs · cysts in dog eyes
Abstract
A clinical syndrome comprising the formation of thin-walled cysts within the posterior chamber, proteinaceous exudation, and pigment dispersion, which typically culminates in glaucoma is recognized in the Golden Retriever breed. Although not uncommon, this syndrome has been relatively infrequently documented in the literature, particularly from a histological standpoint. Fifteen globes from Golden Retrievers presented to Eye Care for Animals between 2003 and 2009 were evaluated by routine hematoxylin and eosin (H&E) as well as immunohistochemical staining. Alcian blue, periodic acid Schiff (PAS), Masson's trichrome, Cytokeratin, Vimentin, Neuron Specific Enolase (NSE), S-100, and smooth muscle actin staining were performed. The thin-walled cysts stained positive with Vimentin, NSE, and S-100 in 15/15 globes, consistent with a ciliary body epithelial cellular origin. No globes demonstrated goniodysgenesis. All 15 globes exhibited free pigment within the trabecular meshwork. Little to no inflammatory infiltrate was noted in 15/15 eyes. These findings suggest that the term 'uveitis' may be an inappropriate description of this syndrome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19883466/