Peer-reviewed veterinary case report
The immune microenvironment in tumors: focus on canine and feline spontaneous neoplasms.
- Journal:
- Frontiers in veterinary science
- Year:
- 2025
- Authors:
- Rizzi, Maddalena et al.
- Affiliation:
- Department of Veterinary Medical Sciences · Italy
Abstract
Companion animals develop spontaneous tumors with biological and immunological features closely resembling human cancers. The tumor microenvironment (TME), particularly its immune infiltrates, plays a pivotal role in tumor progression and immune evasion. This review summarizes current knowledge on the composition and function of immune cells (including T cells, B cells, macrophages, dendritic cells, neutrophils, and mast cells) in the TME of canine and feline tumors. A better understanding of these mechanisms may aid in identifying prognostic biomarkers and novel immunotherapeutic targets in both veterinary and human oncology.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41230456/