Peer-reviewed veterinary case report
The immunomodulatory effect of the antidepressant sertraline in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis.
- Journal:
- Neuroimmunomodulation
- Year:
- 2011
- Authors:
- Taler, Michal et al.
- Affiliation:
- Tel Aviv University
- Species:
- rodent
Abstract
BACKGROUND: We have previously demonstrated the immunomodulatory activity of some selective serotonin reuptake inhibitors. OBJECTIVES: In this research, we performed an in vivo/ex vivo study to evaluate the potential immunosuppressive effect of sertraline in an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. METHODS: Mice (C57/bl EAE) were treated with sertraline (5 mg/kg) or dexamethasone (1 mg/kg) 7 days after EAE induction and then 3 times weekly (for 3 weeks). RESULTS: Sertraline modestly improved the clinical score of EAE and attenuated the disease-induced weight loss. Sertraline also significantly decreased ex-vivo splenocyte viability, proliferation and secretion of pro-inflammatory cytokines in EAE mice. CONCLUSIONS: We suggest that sertraline might be an add-on option for multiple sclerosis treatment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21088435/