Peer-reviewed veterinary case report
How medetomidine and vatinoxan affect heart ultrasound in dogs
By Välimäki, E et al.·Published in Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2024·Evidensia Animal Hospital Tammisto·View original on PubMed →
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Original publication title: The impact of intravenous medetomidine and vatinoxan on echocardiographic evaluation of dogs with stage B1 mitral valve disease.
- Species:
- dog
Plain-English summary
Twelve dogs with stage B1 mitral valve disease were sedated with a combination of medetomidine and vatinoxan to make it easier to perform an echocardiogram without needing to hold them still. After sedation, some heart measurements changed, indicating that while the sedation helped with the procedure, it also affected the heart's function slightly. Importantly, no serious side effects were noted, and the dogs maintained stable blood pressure. This method allowed for a successful echocardiographic evaluation without the stress of manual restraint.
People also search for: dog mitral valve disease treatment · echocardiogram sedation for dogs · heart problems in dogs with mitral valve disease
Abstract
INTRODUCTION/OBJECTIVE: The purpose of this study was to investigate the echocardiographic effects of intravenous medetomidine and vatinoxan in dogs with stage B1 mitral valve disease. We hypothesised medetomidine-vatinoxan would reduce the need for manual restraint during echocardiography without producing detrimental cardiovascular effects or echocardiographic changes. ANIMALS: Twelve client-owned dogs with stage B1 mitral valve disease. METHODS: A transthoracic echocardiographic examination was performed before and after sedation with intravenous medetomidine (10 μg/kg) and vatinoxan (200 μg/kg). Vital parameters were also recorded, and the level of sedation was assessed subjectively. The data were analysed with Student's t-tests with an alpha level of <0.05. RESULTS: End-systolic volume and left ventricular systolic diameter increased (from 0.89 ± 0.19 mL/kg to 1.13 ± 0.29 mL/kg and 0.96 ± 0.12 cm to 1.10 ± 0.10 cm, respectively) and ejection fraction (from 66.33 ± 4.0% to 56.23 ± 9.54%) and fractional shortening (from 36.13 ± 5.42% to 27.24 ± 5.6%) decreased significantly after sedation. End diastolic volume, left ventricular diastolic diameter, and left atrial size remained statistically unchanged, while aortic (from 1.34 ± 0.2 m/s to 0.99 ± 0.14 m/s) and pulmonic (from 0.94 ± 0.16 m/s to 0.66 ± 0.15 m/s) velocities decreased significantly. No dogs had a mean arterial pressure below 65 mmHg. Sedation enabled echocardiographic examination without manual restraint. No adverse effects were observed with the dose studied. CONCLUSIONS: Echocardiographic parameters were not completely comparable with the baseline values, which should be taken into consideration when evaluating dogs sedated with intravenous medetomidine-vatinoxan.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38838577/