The Importance of Pediatric Nonhuman Primate Models in Translational HIV Research.

Abstract

Despite extraordinary global progress in the prevention and treatment of HIV, pediatric HIV remains a significant and under-addressed component of the global epidemic. In her keynote presentation at the Pediatric Nonhuman Primate (NHP) Workshop in October 2024, Dr. Ann Chahroudi delivered a comprehensive and compelling argument for the essential role of pediatric NHP models in translational HIV research. Her talk (summarized below) provided a detailed overview of how infant monkeys have contributed uniquely to our understanding of HIV pathogenesis, immune development, and therapeutic strategies in early life-and why continued investment in these models is critical for advancing pediatric HIV prevention, treatment, and cure.