Peer-reviewed veterinary case report
Bioartificial pancreas implanted in diabetic cat's bone marrow tested
By Yang, Kai-Chiang et al.·Published in Biochemical and biophysical research communications·2010·Department of Organ Reconstruction, Japan·View original on PubMed →
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Original publication title: The in vivo performance of bioartificial pancreas in bone marrow cavity: a case report of a spontaneous diabetic feline.
- Species:
- cat
Plain-English summary
A diabetic cat had a bioartificial pancreas implanted in its bone marrow to help manage its high blood sugar levels. After the surgery, the cat still had elevated blood sugar, but its overall health improved, and the amount of insulin needed lasted longer than before. The blood sugar levels showed some improvement, dropping from very high to more manageable levels. While the cat continued to experience hyperglycemia, the treatment showed some effectiveness, suggesting that this method could be beneficial for diabetic cats in the future.
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Abstract
Recent studies reported that bone marrow cavity offers a widely distributed and well-vascularized microenvironment which is a considerable implantation site for bioartificial pancreas (BAP). In this study, the in vivo performance of BAPs in bone marrow was further demonstrated in a spontaneous diabetes animal. Mouse insulinoma cells encapsulating in agarose gel were enclosed in a calcium phosphate cement chamber to create a BAP. Ten BAPs were implanted into the femur bone marrow cavity of a diabetic feline. The preprandial blood glucose level, 2 h glucose curve, serum C-peptide level and physiological conditions of the recipient were recorded perioperatively. Results showed that the cat still suffered from hyperglycemia postoperatively. However, the physiological conditions of feline were improved with an increase of serum C-peptide level. The peak point of 2 h glucose curve decreased from 400 to 165-290 mg/dl. The efficiency of exogenous insulin extended from 2 to 10-14 h postoperatively which reveals that the implanted BAPs had partial function. This case report revealed that BAPs implanted in the bone marrow cavity for the spontaneous diabetic is effective. The implanted BAPs provided therapeutic benefit despite sustained hyperglycemia. Further study shall be considered to improve the outcomes of BAPs transplantation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20043867/