Peer-reviewed veterinary case report
Esomeprazole and cisapride effects on reflux in anesthetized dogs
By Zacuto, A C et al.·Published in Journal of veterinary internal medicine·2012·Veterinary Medical Teaching Hospital, United States·View original on PubMed →
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Original publication title: The influence of esomeprazole and cisapride on gastroesophageal reflux during anesthesia in dogs.
- Species:
- dog
Plain-English summary
A group of 61 healthy dogs undergoing surgery were monitored for gastroesophageal reflux (GER) during anesthesia. Some dogs received a saline solution, while others were given esomeprazole (a medication to reduce stomach acid) or a combination of esomeprazole and cisapride (which helps with stomach motility). The results showed that the combination of esomeprazole and cisapride significantly reduced the number of reflux episodes compared to the other treatments. This suggests that using both medications together can help prevent GER in dogs during anesthesia.
People also search for: dog reflux during anesthesia · esomeprazole for dogs · cisapride for dogs reflux
Abstract
BACKGROUND: Gastroesophageal reflux (GER) is common in anesthetized dogs and can cause esophagitis, esophageal stricture, and aspiration pneumonia. OBJECTIVE: To determine whether preanesthetic IV administration of esomeprazole alone or esomeprazole and cisapride increases esophageal pH and decreases the frequency of GER in anesthetized dogs using combined multichannel impedance and pH monitoring. ANIMALS: Sixty-one healthy dogs undergoing elective orthopedic surgery procedures. METHODS: Prospective, randomized, placebo-controlled study. Dogs were randomized to receive IV saline (0.9% NaCl), esomeprazole (1 mg/kg) alone, or a combination of esomeprazole (1 mg/kg) and cisapride (1 mg/kg) 12-18 hours and 1-1.5 hours before anesthetic induction. An esophageal pH/impedance probe was utilized to measure esophageal pH and detect GER. RESULTS: Eight of 21 dogs in the placebo group (38.1%), 8 of 22 dogs in the esomeprazole group (36%), and 2 of 18 dogs in the combined esomeprazole and cisapride group (11%) had ≥ 1 episode of GER on impedance testing during anesthesia (P < .05). Esomeprazole was associated with a significant increase in gastric and esophageal pH (P = .001), but the drug did not significantly decrease the frequency of GER (P = .955). Concurrent administration of cisapride was associated with a significant decrease in the number of reflux events (RE) compared to the placebo and esomeprazole groups (P < .05). CONCLUSIONS AND CLINICAL RELEVANCE: Preanesthetic administration of cisapride and esomeprazole decreases the number of RE in anesthetized dogs, but administration of esomeprazole alone was associated with nonacid and weakly acidic reflux in all but 1 dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22489656/