Peer-reviewed veterinary case report
IL-1 and CRP levels in hip joint fluid of dogs with arthritis
By Alves, J C et al.·Published in American journal of veterinary research·2022·Divisã·View original on PubMed →
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Original publication title: The influence of IL-1 and C-reactive protein levels in synovial fluid of companion dogs with bilateral hip osteoarthritis on various clinical disease parameters.
- Species:
- dog
Plain-English summary
A group of police dogs with hip pain due to osteoarthritis had their joint fluid tested for certain proteins to see how they related to their symptoms and overall health. The study found that higher levels of a protein called IL-1 in the joint fluid were linked to more pain and less activity in the dogs. While the exact role of another protein, C-reactive protein (CRP), was unclear, it could indicate inflammation or a better outlook for recovery. This research highlights the importance of monitoring these proteins to help manage hip arthritis in dogs.
People also search for: dog hip pain treatment · osteoarthritis in dogs · IL-1 levels in dog joints · C-reactive protein in dogs · police dog hip arthritis
Abstract
OBJECTIVE: To evaluate IL-1 and C-reactive protein (CRP) levels in the synovial fluid in dogs with bilateral hip osteoarthritis and their relation to animals' clinical, radiographic, and thermographic disease signs. SAMPLE: 100 joints from police working dogs. PROCEDURES: Synovial fluid, IL-1, and CRP levels, weight distribution, joint range of motion, thigh girth, digital thermography, and radiographic signs of the joints were recorded. Data from 4 clinical metrology instruments (CMIs) were collected. Results were compared by age, sex, and Orthopedic Foundation for Animals hip scores with the independent samples t test, ANOVA, and Pearson correlation coefficient (P < .05). RESULTS: The sample included 100 pelvic limbs, equally distributed between left and right pelvic limbs 30 males and 20 females, with a mean age of 6.5 ± 2.4 years and body weight of 26.7 ± 5.2 kg. IL-1 levels, particularly above 200 pg/mL, may be related to the development of caudolateral curvilinear osteophyte, which then expresses a toll on the patient's levels of pain and activity. It was unclear if the CRP levels were a consequence of inflammatory activity within the joint or a reflection of a better prognosis. Increasing body weight was related to worse CMI scores. CLINICAL RELEVANCE: We described the relation of IL-1 and CRP synovial concentration levels with several clinical signs, diagnostic imaging, laboratory findings, and CMI results of animals with osteoarthritis. Further studies are required to determine the interest of each parameter for the prognosis and treatment monitoring.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36087306/