Peer-reviewed veterinary case report
The Integrated Stress Response: A Central Memory Switch in Down Syndrome.
- Journal:
- Cell metabolism
- Year:
- 2020
- Authors:
- Rosi, Susanna & Frias, Elma S
- Affiliation:
- Department of Physical Therapy and Rehabilitation Science · United States
Abstract
Genetic and pharmacological evidence causally demonstrate that the integrated stress response (ISR) is a central molecular switch for long-term memory formation across different species. Zhu et al. (2019) recently demonstrated that persistent activation of the ISR could explain the long-term memory and synaptic plasticity deficits in a mouse model of Down syndrome, the most common genetic cause of intellectual disability.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31951566/