Peer-reviewed veterinary case report
Misoprostol inside the vagina helps abortion with aglepristone
By Agaoglu, A R et al.·Published in Theriogenology·2011·Department of Obstetrics and Gynecology·View original on PubMed →
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Original publication title: The intravaginal application of misoprostol improves induction of abortion with aglepristone.
Plain-English summary
A group of 28 pregnant female dogs, between 25 and 35 days into their pregnancy, were treated with different combinations of medications to induce abortion. The most effective treatment was a combination of aglepristone and misoprostol, which resulted in all pregnancies being terminated within six days. In contrast, other treatments took longer, with some pregnancies not terminating at all. While no severe side effects were noted with most treatments, one group experienced severe vomiting. This study suggests that using both aglepristone and misoprostol together is the best approach for inducing abortion in dogs.
People also search for: dog abortion treatment · aglepristone and misoprostol for dogs · dog pregnancy termination options
Abstract
The aim of the present study was to compare the clinical and endocrinological effects of four different treatments for the induction of abortion in bitches. For this purpose, 28 pregnant bitches between days 25 and 35 of gestation, were randomly assigned to four groups. In group I (n = 7), only aglepristone (AGL, 10mg/kg bw, two injections 24 h apart, s.c.) was administered. In group II (n = 7), AGL (as in group I), cabergolin (CAB, 5 μg/kg, daily p.o., until completion of abortion) and misoprostol (MIS, 200 μg for bitches with ≤ 20 kg bw, 400 μg for bitches with > 20 kg bw, daily intravaginally, until completion of abortion) were administered. In group III (n = 7), AGL (as in group I) and MIS (as in group II) were administered. In group IV (n = 7) AGL, (as in group I) and cloprostenol (CLO, 1μg/kg bw, s.c., two injections 24 h apart with the AGL injections) were combined. In all groups, bitches were examined daily, clinically and ultrasonographically to monitor resorptions/abortions. To measure serum progesterone (P4) and total estrogen (TE) concentrations, blood samples were collected in all groups immediately after the first AGL administration and every other day until completion of abortion. No statistical differences were found between groups concerning the duration until completion of abortion following treatment (n.s.); however, in Group III, 6 d after the start of treatment all pregnancies were terminated whereas in Group I, II and IV, only 57.1% (4/7), 85.7 % (6/7) and 42.8 % (3/7) of pregnancies were terminated. In the latter groups, all pregnancies were terminated between days 8 and 10 after the start of treatment. In Group IV, P4 concentrations on days two and one before the beginning of abortion and the day the abortion started was significantly lower than in the other groups (P < 0.01). No statistical differences were found between groups for TE concentrations (P > 0.05). In Groups I, II and III, no severe side effects occurred. Severe vomiting after each treatment and until the end of abortion was observed in Group IV only. In conclusion, only when a combination of AGL and MIS was used abortion was completed within 6 d in all bitches whereas the additional use of CAB did not improve the treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21458052/