Peer-reviewed veterinary case report
Intravenous blood cell treatment helps dogs with osteoarthritis signs
By Alves, J C et al.·Published in Research in veterinary science·2024·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: The intravenous administration of blood cell secretome can improve clinical signs in dogs with osteoarthritis.
- Species:
- dog
Plain-English summary
A group of 10 dogs with hip osteoarthritis received either an injection of blood cell secretome directly into their hip joints or through an IV to see which worked better. Both treatments helped reduce pain and improve movement, but the joint injection provided longer-lasting relief. The dogs showed significant improvement in their pain levels and overall quality of life after treatment. If your dog has hip arthritis, discussing blood cell secretome treatments with your vet could be beneficial.
People also search for: dog hip arthritis treatment · blood cell secretome for dogs · osteoarthritis pain relief for dogs
Abstract
We aimed to evaluate the effect of the intravenous (IV) administration of blood cell secretome (BCS) compared to its intra-articular (IA) administration. In this cross-over study, ten dogs with bilateral hip osteoarthritis were initially assigned to an IA group (IAG). After a 180-day follow-up, the same 10 animals were assigned to an IV group (IVG). IAG received a single IA administration of 3 ml of BCS per hip joint, and IVG received a single 6 ml IV administration of BCS. Following each treatment, follow-up was conducted on days 0, 8, 15, 30, 60, 90, 120, 150, and 180. In each follow-up, copies of the Canine Brief Pain Inventory (divided into pain interference score - PIS and Pain Severity Score - PSS), Liverpool Osteoarthritis in Dogs (LOAD), and Canine Orthopedic Index (COI, divided into function, gait, stiffness, and quality of life) were obtained. Results were analyzed with the Mann-Whitney test, and Kaplan-Meier estimators were calculated and compared, p < 0.05. The animals had a mean age of 7.6 ± 2.9 years and bodyweight of 27.8 ± 3.6 kg. Seven hips were classified as moderate osteoarthritis, and three as severe. No differences were found between groups from days 0 to +60d, with both groups showing clinically significant improvements. Improvements in the IAG lasted up to +120d. Kaplan-Meier estimators showed that dogs in IAG took longer to record the considered events. IVG also showed positive clinically significant results with different instruments. IV administration of BCS can improve the overall condition of dogs with hip OA, but the IA administration produces longer-lasting results.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39348758/