Peer-reviewed veterinary case report
The Jekyll and Hyde of TREM2.
- Journal:
- Trends in neurosciences
- Year:
- 2020
- Authors:
- Rueda-Carrasco, Javier & Hong, Soyon
- Affiliation:
- UK Dementia Research Institute at University College London · United Kingdom
Abstract
In a recent paper, Gratuze et al. demonstrated a putative neuroprotective role of a key Alzheimer risk variant, TREM2, against tau-mediated neurodegeneration in a mouse model of tauopathy. This study highlights the context-dependent response of microglia, and proposes antagonistic roles of TREM2 in Aβ- versus tau-mediated pathology.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32863043/