Peer-reviewed veterinary case report
The K/BxN arthritis model.
- Journal:
- Current protocols in immunology
- Year:
- 2008
- Authors:
- Monach, Paul A et al.
- Affiliation:
- Harvard Medical School · United States
- Species:
- rodent
Abstract
Mice expressing both the T cell receptor (TCR) transgene KRN and the MHC class II molecule A(g7) (K/BxN mice) develop severe inflammatory arthritis, and serum from these mice causes a similar arthritis in a wide range of mouse strains, due to autoantibodies recognizing glucose-6-phosphate isomerase (GPI). K/BxN transgenic mice have been useful for investigating the development of autoimmunity, and the serum transfer model has been particularly valuable in eliciting mechanisms by which anti-GPI autoantibodies induce joint-specific inflammation. This unit describes detailed methods for the maintenance of a K/BxN colony, induction of arthritis by serum transfer, clinical evaluation of arthritis, and measurement of anti-GPI antibodies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18491295/