Peer-reviewed veterinary case report
The KasA inhibitor JSF-3285 improves the sterilizing activity of bedaquiline-pretomanid-containing regimens in a mouse model of tuberculosis.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2025
- Authors:
- Soni, Heena et al.
- Affiliation:
- Department of Medicine · United States
Abstract
JSF-3285 is a promising preclinical candidate for tuberculosis that potently targets theβ-ketoacyl-ACP synthase KasA. In mouse models of acute, sub-acute, chronic, and relapse infection, JSF-3285 offers substantial activity in combination with bedaquiline and pretomanid, which could be applicable for both drug-sensitive and drug-resistant infections.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40265947/