Peer-reviewed veterinary case report
The latest model has just arrived! A new experimental mouse model of PLA2R1-associated membranous nephropathy.
- Journal:
- Kidney international
- Year:
- 2023
- Authors:
- Beck, Laurence H
- Affiliation:
- Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center · United States
Abstract
Much akin to the explosion in number of known target antigens in membranous nephropathy, there has been a rapid expansion in the availability of animal models involving the first 2 antigens discovered in adult disease, phospholipase A2 receptor and thrombospondin type 1 domain-containing 7A. In this issue, Tomas et al. describe a novel mouse model of phospholipase A2 receptor-associated membranous nephropathy that shows great promise for investigating molecular mechanisms of disease and as an experimental system for testing existing and emerging therapies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37863634/