Peer-reviewed veterinary case report
PTTG1 gene levels predict tumor return after dog pituitary surgery
By Vastenhout, N et al.·Published in Veterinary journal (London, England : 1997)·2018·Utrecht University, Netherlands·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas.
- Species:
- dog
Plain-English summary
A dog with a corticotroph pituitary adenoma, a type of tumor causing high cortisol levels, was studied to see how a specific gene (PTTG1) related to the chances of the tumor coming back after surgery. It was found that dogs with higher levels of this gene had a much shorter time without disease compared to those with lower levels. This suggests that measuring PTTG1 could help predict how likely it is for the tumor to return after treatment. Understanding this could help veterinarians better manage dogs with this condition.
People also search for: dog pituitary tumor treatment · corticotroph adenoma prognosis · high cortisol levels in dogs
Abstract
Pituitary-dependent hypercortisolism (PDH) is a common endocrinopathy in dogs, but the promotors and initiators of the tumourigenesis of corticotroph pituitary adenomas remain unknown. Based on human data, we investigated mRNA expression of pituitary tumour transforming gene 1 (PTTG1) with quantitative RT-PCR in canine corticotroph pituitary adenomas. PTTG1 was overexpressed in adenomas approximately 3-fold. A strong association was observed between PTTG1 expression and disease-free interval; dogs with high PTTG1 expression had a significantly (4 times; P=0.02) shorter disease-free interval than dogs with low PTTG1 expression. This paper shows that PTTG1 expression is a negative prognosticator in relation to disease-free interval and recurrence in dogs undergoing transsphenoidal hypophysectomy as treatment for PDH.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30268327/