Peer-reviewed veterinary case report
Major new dust mite allergen Zen-1 found in dogs with atopic
By Olivry, Thierry et al.·Published in Veterinary dermatology·2017·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: The novel high molecular weight Dermatophagoides farinae protein Zen-1 is a major allergen in North American and European mite allergic dogs with atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin condition caused by allergies) were found to have a strong allergic reaction to a newly identified allergen called Zen-1, which comes from a common dust mite. In tests, 86% of these dogs showed sensitivity to Zen-1, compared to much lower rates for other known mite allergens. This suggests that Zen-1 is a significant cause of allergic reactions in affected dogs. Understanding this can help veterinarians better diagnose and treat allergic skin issues in dogs.
People also search for: dog skin allergies treatment · atopic dermatitis in dogs · dust mite allergy in dogs
Abstract
BACKGROUND: Atopic dogs with hypersensitivity to Dermatophagoides farinae (Df) have IgE recognizing high molecular weight (MW) allergens more often than the low MW Der f 1 and 2. A new high MW Df allergen, Zen-1, has been identified recently. OBJECTIVES: To determine the IgE reactivity of American and European Df-hypersensitive dogs to Zen-1, Der f 1 and Der f 2. METHODS: We tested sera from 33 Df-reactive dogs from the USA, 29 from Europe and 15 experimentally sensitized to Df, by ELISA against crude Df, Der f 1, Der f 2 and Zen-1. ELISA inhibition was performed with sera reactive to Zen-1. Intradermal testing (IDT) was also done with the same allergens in 25 other American atopic dogs. RESULTS: Altogether, IgE seropositivity to Zen-1 was more prevalent (86%) than that to Der f 1 (17%) or Der f 2 (19%). The IgE reactivity to Zen-1 was correlated to that against crude Df; this allergen alone inhibited a high percentage (median: 50%; range: 22-84%) of the binding to the crude mite extract. The seropositivity to low MW allergens was highest in experimentally sensitized dogs. Serum IgE recognition of Der f 1 was low in dogs with AD; that to Der f 2 was significantly lower in American dogs (6%) than in European ones (28%). A high prevalence of positive immediate IDT reactions to Zen-1 confirmed the likely relevance of serological results. CONCLUSIONS AND CLINICAL IMPORTANCE: This study establishes Zen-1 as a major allergen in atopic dogs sensitized to Df.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28261917/