Peer-reviewed veterinary case report
The ototoxic effects of ethacrynic acid in man and animals.
- Journal:
- The Laryngoscope
- Year:
- 1976
- Authors:
- Matz, G J
Plain-English summary
This study looked at the harmful effects of a medication called ethacrynic acid on hearing in both people and animals. It reviewed how this drug affects the balance of certain fluids in the inner ear and how it impacts hearing responses. The researchers examined tissue samples from animals that had received the drug and found some swelling and changes in the ear structures, especially in those that got higher doses. However, it was noted that long-term use of ethacrynic acid did not lead to lasting damage to hearing. Overall, the treatment did not cause permanent hearing problems.
Abstract
A review of the literature was carried out to summarize the ototoxic effects of ethacrynic acid on man and animal. The effects of this drug on the electrolytes of the endolymphatic and perilymphatic systems, on the cochlear potentials and the auditory cortical-evoked responses, were reviewed. Histological animal studies determined by light and electron microscopy were described. Potentiation of this drug with previous aminoglycoside therapy was discussed. In this paper, a human case report with temporal bone findings was present in addition to the histopathological effects of this drug which were shown in a series of animals receiving this drug over a period of time. Edematous and cellular changes in the stria vascularis, especially with animals receiving large doses of the drug, were described. No permanent alterations in the cochlear potentials resulted from the long-term therapy with ethacrynic acid.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/1084946/