Peer-reviewed veterinary case report
How blocking PI3K pathway can stop dog mast cell tumor growth
By Amagai, Yosuke et al.·Published in The Journal of veterinary medical science·2013·Graduate School of Bio-Applications and System Engineering, Japan·View original on PubMed →
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Original publication title: The phosphoinositide 3-kinase pathway is crucial for the growth of canine mast cell tumors.
- Species:
- dog
Plain-English summary
Mast cell tumors (MCTs) are the most common type of skin tumor in dogs, making up about 16-21% of all skin tumors. Current treatments, like imatinib mesylate, have a response rate of less than 50%, meaning many dogs don’t see improvement. Research has shown that a specific signaling pathway called the phosphoinositide 3-kinase (PI3K) pathway plays a key role in the growth of these tumors. Targeting this pathway could lead to new treatment options for dogs suffering from MCTs, potentially improving outcomes for affected pets.
People also search for: dog mast cell tumor treatment · canine skin tumor options · imatinib for dog tumors · mast cell tumor prognosis in dogs
Abstract
Mast cell tumors (MCTs) are the most common tumors in dogs, accounting for 16-21% of cutaneous tumors. Although several small molecule inhibitors, including imatinib mesylate, have been used for the treatment of MCTs, the response rate remains less than 50%. In this study, the effects of different selective signal inhibitors on MCT cell growth were evaluated using 4 different cell lines derived from dogs. We found that the phosphoinositide 3-kinase (PI3K) signaling pathway is crucial for the proliferation of MCT cells in the presence or absence of c-kit gene mutations. Here, we propose a novel therapeutic strategy to target the PI3K pathway for the treatment of canine MCTs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23328607/