Peer-reviewed veterinary case report
ABCB1 gene mutation rates in European dog breeds at risk
By Firdova, Zuzana et al.·Published in Research in veterinary science·2016·Department of Molecular Biology·View original on PubMed →
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Original publication title: The prevalence of ABCB1:c.227_230delATAG mutation in affected dog breeds from European countries.
- Species:
- dog
Plain-English summary
A study found that certain dog breeds, like Smooth Collies and Australian Shepherds, may have a genetic mutation that makes them sensitive to certain medications, particularly those used for parasite control, like ivermectin. This mutation affects how their bodies process these drugs, which can lead to serious side effects if they are given the wrong dosage. The research showed high rates of this mutation in breeds such as Smooth Collies (58.5%) and Rough Collies (48.3%). Understanding this genetic risk can help veterinarians prescribe safer treatments for these breeds.
People also search for: dog breeds sensitive to ivermectin · Smooth Collie medication safety · Australian Shepherd drug sensitivity
Abstract
Deletion of 4-base pairs in the canine ABCB1 (MDR1) gene, responsible for encoding P-glycoprotein, leads to nonsense frame-shift mutation, which causes hypersensitivity to macrocyclic lactones drugs (e.g. ivermectin). To date, at least 12 purebred dog breeds have been found to be affected by this mutation. The aim of this study was to update information about the prevalence of ABCB1 mutation (c.227_230delATAG) in predisposed breeds in multiple European countries. This large scale survey also includes countries which were not involved in previous studies. The samples were collected in the period from 2012 to 2014. The overview is based on genotyping data of 4729 individuals. The observed mutant allele frequencies were 58.5% (Smooth Collie), 48.3% (Rough Collie), 35% (Australian Shepherd), 30.3% (Shetland Sheepdog), 28.1% (Silken Windhound), 26.1% (Miniature Australian Shepherd), 24.3% (Longhaired Whippet), 16.2% (White Swiss Shepherd) and 0% (Border Collie). The possible presence of an ABCB1 mutant allele in Akita-Inu breed has been investigated with negative results. This information could be helpful for breeders in optimization of their breeding strategy and for veterinarians when prescribing drug therapy for dogs of predisposed breeds.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27234542/