Peer-reviewed veterinary case report
The preventive effect of mitomycin-C on the external auditory canal fibrosis in an experimentally induced animal model.
- Journal:
- American journal of otolaryngology
- Year:
- 2010
- Authors:
- Yoon, Yeo-Hoon et al.
- Affiliation:
- Department of Otolaryngology-Head and Neck Surgery · South Korea
- Species:
- rodent
Abstract
OBJECTIVE: The aim of this study was to investigate the preventive effect of mitomycin-C (MMC) on external auditory canal (EAC) fibrosis in an animal model. STUDY DESIGN: This is a randomized, controlled animal study. SUBJECTS AND METHODS: Sixteen guinea pigs were used for this study. After the skin of cartilaginous EAC was injured with an electrocautery, the cottonoid soaked in MMC solution with concentration of 0.4 mg/mL was topically applied for 5 minutes to the injured EAC in an MMC-treated group (n = 8). In addition, saline was applied in the control group (n = 8). At 4 weeks after injury, postsurgical changes of EAC were evaluated by histologic examination. RESULTS: External auditory canal fibrosis was induced by injury with electrocautery. The MMC-treated group showed less degree of fibrosis without differences in epithelialization and inflammatory cell infiltration. CONCLUSION: This study suggests that MMC can be helpful in preventing EAC fibrosis after injury.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19944892/