Peer-reviewed veterinary case report
Urine lipid changes in cats with bacterial bladder infection
By Kobayashi, Yui et al.·Published in The Journal of veterinary medical science·2021·Department of Animal Radiology, Japan·View original on PubMed →
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Original publication title: The profile of urinary lipid metabolites in cats with bacterial cystitis.
- Species:
- cat
Plain-English summary
A group of cats with bacterial cystitis (a urinary tract infection) had higher levels of certain fatty acids and their breakdown products in their urine compared to healthy cats. Specifically, the levels of arachidonic acid (ARA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) were elevated, indicating increased inflammation. This information could help veterinarians better understand and diagnose bacterial cystitis in cats.
People also search for: cat urinary tract infection symptoms · bacterial cystitis treatment in cats · elevated fatty acids in cat urine
Abstract
Bacterial cystitis is one of the feline lower urinary tract diseases (FLUTDs). Polyunsaturated fatty acids, such as arachidonic acid (ARA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), are oxidized into various lipid mediators that modulate inflammation. Since the profile of lipid metabolites excreted in urine is useful for assessing inflammatory body conditions, we analyzed 126 types of urinary lipid metabolites in cats with bacterial cystitis. Using LC-MS/MS, we found that the levels of 11 metabolites were higher in the urine of cystitis cats than in the urine of healthy cats. In detail, the urinary levels of ARA, EPA, and DHA and eight of their metabolites were increased in cystitis cats. Focusing on the lipid oxidation pathway, the urinary levels of four cyclooxygenase-, three lipoxygenase-, and one cytochrome P450-dependent oxidated metabolites were increased in bacterial cystitis. These urinary lipid profiles can provide some insight into the pathology and future diagnosis of bacterial cystitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34744098/