Peer-reviewed veterinary case report
CSF test results predict recovery in dogs with no deep pain from disc
By Chamisha, Y et al.·Published in Research in veterinary science·2015·Department of Neurology and Neurosurgery·View original on PubMed →
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Original publication title: The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation.
- Species:
- dog
Plain-English summary
A group of 31 dogs with severe back problems caused by a herniated disc were brought in because they couldn't feel pain in their back legs. After surgery to relieve pressure on the spine, the veterinarians examined their cerebrospinal fluid (CSF) to see if it could help predict recovery. They found that certain levels of immune cells in the CSF could indicate whether the dogs would regain their ability to feel pain and walk again. Unfortunately, dogs with higher levels of these cells were less likely to recover within ten days after surgery.
People also search for: dog back leg paralysis · dog herniated disc treatment · dog surgery recovery prognosis
Abstract
Providing a pre-operative prognosis for dogs presented with absent deep pain perception (DPP) is extremely challenging, as the overall recovery rates widely vary. This study assesses the possible correlation between the severity of spinal cord injury and CSF cytology in 31 paraplegic dogs presented with absent DPP due to acute thoracolumbar intervertebral disc herniation (TL-IVDH). All dogs underwent surgical decompression immediately following diagnosis. CSF TNCC, macrophage percentage and macrophage to monocyte (MΦ:M) ratio were significantly higher in dogs that failed to regain DPP within 10 days post-operatively and in dogs that failed to regain ambulation at the end of the study period (P< 0.05). MΦ:M of 0.73 and higher corresponded to a sensitivity of 54% and specificity of 100% for prediction of a negative long-term outcome. CSF TNCC, macrophage percentage and MΦ:M ratio effectively predicted regaining DPP and the long-term outcome in dogs that lost DPP due to acute TL-IVDH.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25957960/