Peer-reviewed veterinary case report
The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction.
- Journal:
- Infection and immunity
- Year:
- 2007
- Authors:
- Shi, Xiaoju et al.
- Affiliation:
- Institute of Cell and Molecular Science · United Kingdom
Abstract
The rag locus of Porphyromonas gingivalis encodes a putative TonB-dependent outer membrane receptor, RagA, and a 55-kDa immunodominant antigen, RagB. Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17283109/