Peer-reviewed veterinary case report
The regenerative medicine laboratory: facilitating stem cell therapy for equine disease.
- Journal:
- Clinics in laboratory medicine
- Year:
- 2011
- Authors:
- Borjesson, Dori L & Peroni, John F
- Affiliation:
- Department of Pathology · United States
- Species:
- horse
Plain-English summary
This article talks about a new area of medicine for horses called regenerative medicine, which uses special cells called mesenchymal stem cells (MSCs) to help treat joint and bone problems. It explains how these cells are collected from sources like bone marrow, fat, and placental tissues, and how they are prepared for use in treatments. The article also highlights that the methods used for horses are similar to those used for people, but there are more options for using these cells in horses than in human medicine. Overall, the use of MSCs in treating orthopedic diseases in horses is becoming more common and shows promise for healing.
Abstract
This article focuses on the emerging field of equine regenerative medicine with an emphasis on the use of mesenchymal stem cells (MSCs) for orthopedic diseases. We detail laboratory procedures and protocols for tissue handling and MSC isolation, characterization, expansion, and cryopreservation from bone marrow, fat, and placental tissues. We provide an overview of current clinical uses for equine MSCs and how MSCs function to heal tissues. Current laboratory practices in equine regenerative medicine mirror those in the human field. However, the translational use of autologous and allogeneic MSCs for patient therapy far exceeds what is currently permitted in human medicine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21295725/