Peer-reviewed veterinary case report
How blood pressure hormones differ in Greyhounds and other dogs
By Martinez, J et al.·Published in Journal of veterinary internal medicine·2017·Department of Veterinary Biosciences, United States·View original on PubMed →
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Original publication title: The Renin-Angiotensin-Aldosterone System in Greyhounds and Non-Greyhound Dogs.
- Species:
- dog
Plain-English summary
A group of healthy Greyhounds had higher blood pressure and sodium levels compared to other dogs, but their levels of a hormone called aldosterone were lower. This is interesting because it suggests that Greyhounds have a unique way of managing their blood pressure and kidney function. The study found that while Greyhounds had higher sodium and creatinine levels, their overall hormone activity related to blood pressure regulation was similar to non-Greyhound dogs. This means that Greyhounds might have a different but effective way of keeping their blood pressure in check.
People also search for: Greyhound blood pressure · dog kidney function · high sodium levels in dogs · Greyhound health issues · aldosterone levels in dogs
Abstract
BACKGROUND: The renin-angiotensin-aldosterone system (RAAS) regulates blood pressure, electrolyte homeostasis, and renal function. Blood pressure, serum sodium concentrations, and urinary albumin excretion are higher in Greyhounds than other purebred and mixed-breed dogs. HYPOTHESIS: Alterations in the RAAS in Greyhounds are associated with hemodynamic and clinicopathologic differences observed in the breed. ANIMALS: Clinically healthy Greyhound and non-Greyhound dogs consecutively enrolled as blood donors (n = 20/group). METHODS: Prospective study. Standard chemical analysis was performed on serum and urine. Serum angiotensin-converting enzyme (ACE) activity was determined by fluorometric assay. All other RAAS hormones were determined by radioimmunoassay. Symmetric dimethylarginine (SDMA) was measured by immunoassay. Measurements were compared to blood pressure and urine albumin concentration. Data are presented as mean ± SD or median, range. RESULTS: Serum creatinine (1.5 ± 0.2 vs 1.0 ± 0.1 mg/dL, P < .001), sodium (149, 147-152 vs 148, 146-150 mEq/L, P = .017), and SDMA (16.1 ± 2.9 vs 12.2 ± 1.8 μg/dL, P < .001) were significantly higher in Greyhounds versus non-Greyhounds, respectively. Plasma renin activity (0.69, 0.10-1.93 vs 0.65, 0.27-2.93 ng/mL/h, P = .60) and ACE activity (4.5, 2.1-8.5 vs 4.6, 2.1-11.4 activity/mL; P = .77) were similar between groups and did not correlate with higher systolic pressures and albuminuria in Greyhounds. Plasma aldosterone concentration was significantly lower in Greyhounds versus non-Greyhounds (11, 11-52 vs 15, 11-56 pg/mL, respectively, P = .002). CONCLUSIONS AND CLINICAL IMPORTANCE: Basal RAAS activation did not differ between healthy Greyhounds and non-Greyhounds. Lower aldosterone concentration in Greyhounds is an appropriate physiologic response to higher serum sodium concentration and blood pressure, suggesting that angiotensin II effects in the renal tubule predominate over those of aldosterone.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28488321/