Peer-reviewed veterinary case report
The role of regulatory T cells during the attenuation of graft-versus-leukemia activity following donor leukocyte infusion in mice.
- Journal:
- Leukemia research
- Year:
- 2011
- Authors:
- Choi, Mi-Sun et al.
- Affiliation:
- Department of Internal Medicine · South Korea
- Species:
- rodent
Abstract
We investigated how the graft-versus-leukemia (GVL) effect is attenuated in the tumor microenvironment using a murine model of non-myeloablative allo-HSCT (NM-HSCT) plus delayed donor leukocyte infusion (DLI) in a haploidentical B6→F1 strain combination. In-line with aggravated leukemia growth, the proportions of effector T cells expressing IFN-γ (Teffs) in spleen were reduced and attenuated GVL activity was found to be accompanied by a rebound in CD4(+)Foxp3(+) regulatory T cells (Tregs) in tumor-draining lymph nodes and tumor tissues. DLI-derived Tregs and Teffs may be potential indicators of presence of leukemic progression after DLI in this GVL model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21782242/