Peer-reviewed veterinary case report
Safety of DepoFoam bupivacaine for wound pain in rabbits and dogs
By Richard, Brigitte M et al.·Published in Expert opinion on investigational drugs·2011·Clinical Research & Drug Safety Assessment, United States·View original on PubMed →
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Original publication title: The safety and tolerability evaluation of DepoFoam bupivacaine (bupivacaine extended-release liposome injection) administered by incision wound infiltration in rabbits and dogs.
- Species:
- rabbit
Plain-English summary
A group of rabbits and dogs received a new pain relief injection called DepoFoam bupivacaine after surgery to see if it was safe and effective. The injection was given directly into the surgical site, and researchers monitored the animals for any side effects or issues with healing. While some rabbits showed mild inflammation at the injection site, there were no serious adverse effects in either species. Overall, the study found that the injection was safe and did not negatively impact wound healing.
People also search for: dog surgery pain relief · rabbit surgery recovery · DepoFoam bupivacaine safety
Abstract
OBJECTIVE: DepoFoam bupivacaine (DB) is in development for prolonged postoperative analgesia. Studies were conducted to evaluate the potential local and systemic toxicity and any effect on wound healing after wound infiltration. METHODS: The model simulates an inguinal hernia (skin incision ∼2.5 and 5.5 cm). Animals (four/sex/group of each species) received DB 9, 18 or either 25 or 30 mg/kg, bupivacaine solution (B(sol); 7.5 mg/ml, 9 mg/kg) or saline. DB was given at 0.6, 1.2 and 1.0 or 1.2 ml/kg, respectively, and B(sol) or saline at 1.2 ml/kg. Each dose was infiltrated in small fractions on Day 1. End points included histology on Days 3 and 15. Wound healing was recorded on Day 2 through Day 15. RESULTS: There was no adverse effect in either species. Notably, granulomatous inflammation was noted in surgical sites from 8 of 24 rabbits in the DB groups only. Based on the minimal to mild severity on Day 15, this was considered a normal reaction against the liposomes. Except for granulomatous inflammation, there were no differences in overall incidence or severity of histologic changes in the sites dosed to DB, saline or B(sol). CONCLUSIONS: The data reported here are the first demonstration of the safety of DB in toxicology species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21867476/