Peer-reviewed veterinary case report
Amitriptyline not effective for short-term cat urinary disease
By Kraijer, M et al.·Published in Journal of Feline Medicine and Surgery·2003·Hospital for Small Animals, University of Edinburgh, Easter Bush, Roslin, Edinburgh EH25 9RG, Scotland, UK, United Kingdom·View original on Crossref →
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Original publication title: The short-term clinical efficacy of amitriptyline in the management of idiopathic feline lower urinary tract disease: A controlled clinical study
- Species:
- cat
Plain-English summary
A group of cats with urinary problems were treated with either a daily dose of amitriptyline or a placebo to see if it would help their idiopathic feline lower urinary tract disease (FLUTD). After a week, the results showed no significant improvement in symptoms for those taking amitriptyline compared to those on the placebo. This suggests that amitriptyline may not be effective for short-term relief of FLUTD symptoms. Further research is needed to explore its long-term effects, which might take several weeks to become apparent.
People also search for: cat urinary problems treatment · amitriptyline for cat FLUTD · feline lower urinary tract disease symptoms
Abstract
In a controlled study, the effects of amitriptyline compared with that of a placebo in cats suffering from idiopathic Feline Lower Urinary Tract Disease (FLUTD) have been investigated. Thirty-six animals were selected by veterinary practitioners and treated with a placebo or 10 mg amitriptyline once daily. All animals received concomitant antibiotic treatment. A total of 24 cats were included in the final assessment of the results. The severity of symptoms before and after treatment were compared between groups and showed no significant difference. Results indicated that the 7-day course of 10 mg amitriptyline was not effective in the treatment of idiopathic FLUTD. Thus, it is considered not to be beneficial as a short-term therapy where the therapeutic results depend on peripheral effects of the drug. Long-term effects may be expected 4 or more weeks after the start of therapy and need to be further investigated.
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Search related cases →Original publication on Crossref: https://doi.org/10.1016/s1098-612x(03)00004-4