The significance of neural electrophysiological and functional effects of cervical spinal ganglia and sympathetic ganglia in cervical vertigo.

Abstract

This study investigates the neural electrophysiological and functional effects of cervical spinal ganglia and sympathetic ganglia in cervical vertigo. Twenty-eight rabbits were randomized into superior cervical sympathetic ganglia (SCSG) group (n&#xa0;=&#xa0;8), inferior cervical sympathetic ganglia (ICSG) group (n&#xa0;=&#xa0;8) and control groups for both SCSG and ICSG (n&#xa0;=&#xa0;6 each). Calcium indicator CaMPARI2 was injected into the ganglia. Four weeks later, both SCSG and ICSG groups underwent electrical stimulation followed by UV irradiation. Control groups did not receive electrical stimulation but were also injected with the calcium indicator and irradiated by UV. Additionally, 63 rabbits were randomized into three groups: cervical spinal ganglia stimulation (n&#xa0;=&#xa0;21), paravertebral nerve blockage (n&#xa0;=&#xa0;21), and simultaneous blockage of paravertebral nerve and cervical spinal ganglia (n&#xa0;=&#xa0;21), all subjected to the same electrical stimulation protocol. Results indicated that calcium concentration in the cervical sympathetic ganglia after stimulation was significantly higher compared to the control group (P&#xa0;<&#xa0;0.05). Blood flow changes in both vertebral artery and basilar artery were significant after electrical stimulation (P&#xa0;<&#xa0;0.05). In the paravertebral nerve blockage group, significant changes in basilar artery blood flow were observed (P&#xa0;<&#xa0;0.05), while no significant blood flow changes were noted in the simultaneous blockage group. Cervical spinal ganglia and sympathetic ganglia in the pathogenesis of cervical vertigoThese findings underscore the importance of neural electrophysiological and functional effects of cervical spinal ganglia and sympathetic ganglia in the pathogenesis of cervical vertigo.