Peer-reviewed veterinary case report
The skin as a site of initiation of systemic autoimmune disease: new opportunities for treatment.
- Journal:
- The Journal of investigative dermatology
- Year:
- 2006
- Authors:
- Dutz, Jan P
- Affiliation:
- Departments of Dermatology and Medicine and Child & Family Research Institute · Canada
Abstract
Dendritic cells are the coordinators of the adaptive immune response. Chronic activation of skin dendritic cells by keratinocyte expression of CD40 ligand (CD40L; CD154) leads to autoimmunity. In this issue, systemic administration of tacrolimus is shown by Loser et al. to effectively treat autoimmunity in a murine model involving transgenic keratinocyte expression of CD40L.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16702968/