Peer-reviewed veterinary case report
The STR/ort mouse model of spontaneous osteoarthritis - an update.
- Journal:
- Osteoarthritis and cartilage
- Year:
- 2017
- Authors:
- Staines, K A et al.
- Affiliation:
- Roslin Institute and R(D)SVS · United Kingdom
Abstract
Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27965138/