Peer-reviewed veterinary case report
MRI sign that helps identify brain tumors in dogs
By Garcia-Mora, Josefa et al.·Published in Journal of veterinary internal medicine·2023·Department of Small Animal Clinical Sciences and Animal Cancer Care and Research Center, United States·View original on PubMed →
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Original publication title: The T2-FLAIR mismatch sign as an imaging biomarker for oligodendrogliomas in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with brain tumors underwent MRI scans to look for a specific imaging sign called the T2-FLAIR mismatch (T2FMM). This sign was found in 14 out of 186 dogs, and all of these dogs had oligodendrogliomas, a type of brain tumor. The presence of the T2FMM was linked to low-grade tumors and certain changes in the tumor's structure. This finding suggests that the T2FMM could help veterinarians identify oligodendrogliomas more accurately during MRI evaluations.
People also search for: dog brain tumor symptoms · MRI for dog brain tumor · oligodendroglioma in dogs
Abstract
BACKGROUND: In humans, the T2-weighted (T2W)-fluid-attenuated inversion recovery (FLAIR) mismatch sign (T2FMM) is a specific imaging biomarker for the isocitrate dehydrogenase 1 (IDH1)-mutated, 1p/19q non-codeleted low-grade astrocytomas (LGA). The T2FMM is characterized by a homogeneous hyperintense T2W signal and a hypointense signal with a hyperintense peripheral rim on FLAIR sequences. In gliomas in dogs, the T2FMM has not been described. HYPOTHESES/OBJECTIVES: In dogs with focal intra-axial brain lesions, T2FMM will discriminate gliomas from other lesions. The T2FMM will be associated with the LGA phenotype and presence of microcysts on histopathology. Interobserver agreement for T2FMM magnetic resonance imaging (MRI) features will be high. ANIMALS: One hundred eighty-six dogs with histopathologically diagnosed focal intra-axial lesions on brain MRI including oligodendrogliomas (n = 90), astrocytomas (n = 47), undefined gliomas (n = 9), cerebrovascular accidents (n = 33), and inflammatory lesions (n = 7). METHODS: Two blinded raters evaluated the 186 MRI studies and identified cases with the T2FMM. Histopathologic and immunohistochemical slides of T2FMM cases were evaluated for morphologic features and IDH1-mutations and compared to cases without the T2FMM. Gene expression analyses were performed on a subset of oligodendrogliomas (n = 10) with and without T2FMM. RESULTS: The T2FMM was identified in 14/186 (8%) of MRI studies, and all dogs with T2FMM had oligodendrogliomas (n = 12 low-grade [LGO], n = 2 high-grade [HGO]; P < .001). Microcystic change was significantly associated with the T2FMM (P < .00001). In oligodendrogliomas with T2FMM, IDH1-mutations or specific differentially expressed genes were not identified. CONCLUSION AND CLINICAL IMPORTANCE: The T2FMM can be readily identified on routinely obtained MRI sequences. It is a specific biomarker for oligodendroglioma in dogs, and was significantly associated with non-enhancing LGO.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37246729/