Peer-reviewed veterinary case report
Healing chronic corneal ulcers in dogs with cell secretions
By Casado-Santos, Alejandro et al.·Published in Research in veterinary science·2025·Department of Surgery, Spain·View original on PubMed →
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Original publication title: The therapeutic potential of mesenchymal stromal cell secretome in treating spontaneous chronic corneal epithelial defects in dogs.
- Species:
- dog
Plain-English summary
A group of ten dogs with chronic corneal ulcers, which caused symptoms like squinting, red eyes, and sensitivity to light, were treated with eye drops made from a special cell secretome derived from fat tissue. Remarkably, all the dogs healed completely within about 1.2 weeks, even those that hadn’t improved with other treatments. The dogs showed quick relief from their symptoms after starting the secretome therapy, and there were no side effects reported. This new treatment option appears to be safe and effective for dogs suffering from complicated corneal ulcers.
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Abstract
Corneal ulcers in dogs pose a significant challenge in veterinary ophthalmology, often leading to prolonged visual impairment and discomfort. This study aimed to assess the efficacy of adipose tissue-derived mesenchymal stromal cell (ASCs) secretome as a treatment for complicated corneal ulcers in dogs. Ten dogs with spontaneous chronic corneal epithelial defects, were treated with topical application of ASC secretome eye drops. Our results showed that secretome therapy facilitated complete healing of all corneal ulcers within 4 weeks, with an average healing time of 1.2 weeks. Notably, secretome treatment was effective even in cases that had previously failed to respond to conventional therapies. Clinical signs such as blepharospasm, conjunctival hyperemia, and photophobia were alleviated promptly following secretome administration. Secretome therapy was well-tolerated, with no adverse reactions reported, further supporting its safety profile. The findings suggest that ASC secretome represents a promising cell-free and minimally invasive therapeutic approach for the treatment of complicated corneal ulcers in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39923345/