Peer-reviewed veterinary case report
How misoprostol protects dogs' stomachs from aspirin bleeding
By Bowersox, T S et al.·Published in Journal of the American Animal Hospital Association·1996·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: The use of a synthetic prostaglandin E1 analog as a gastric protectant against aspirin-induced hemorrhage in the dog.
- Species:
- dog
Plain-English summary
Ten dogs were given aspirin for ten days to see if it caused stomach bleeding. While all the dogs on aspirin alone developed stomach issues, those that also received a medication called misoprostol showed much less damage. In fact, four out of five dogs on misoprostol had no stomach problems at all. Some dogs did experience diarrhea, but this stopped when the dose of misoprostol was lowered. Overall, misoprostol helped protect the dogs' stomachs from the harmful effects of aspirin.
People also search for: dog aspirin side effects · dog stomach bleeding treatment · misoprostol for dogs diarrhea
Abstract
Misoprostol prevented gastric hemorrhage in dogs, each of which received aspirin (35 mg/kg body weight, orally q 8 hrs for 10 days). All dogs receiving aspirin alone had gastroscopic and histopathological lesions. No lesions were noted in four of five dogs given aspirin plus misoprostol (15 micrograms/kg body weight, q 8 hrs for five days; then 7.5 micrograms/kg body weight, q 8 hrs for five days). Four of 10 dogs receiving 15 micrograms/kg body weight of misoprostol developed diarrhea. The misoprostol dose was reduced to 7.5 micrograms/kg body weight, and the diarrhea subsided.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8875355/