Peer-reviewed veterinary case report
Stem cell treatment for spinal joint disease in dogs
By Kemilew, Jerzy et al.·Published in In vivo (Athens, Greece)·2019·"Kemilew Stem Cells for Animals" Company·View original on PubMed →
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Original publication title: The Use of Allogenic Stromal Vascular Fraction (SVF) Cells in Degenerative Joint Disease of the Spine in Dogs.
- Species:
- dog
Plain-English summary
A group of 10 dogs aged 6 to 13 years with degenerative joint disease in the spine received an injection of stem cells to help reduce pain and improve movement. Within a few days after the treatment, the dogs showed less pain and reduced limping. Blood tests indicated that a substance related to healing (VEGF) increased shortly after treatment, suggesting that the stem cells were helping the dogs recover. Overall, the stem cell therapy appeared to have a positive effect on their condition, leading to better mobility and comfort.
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Abstract
BACKGROUND/AIM: Stem cells are widely used in regenerative medicine and in clinical practice for the treatment of damaged nerve tissue, myocytes, tendons, and ligaments. The aim of the study was to monitor VEGF levels after the administration of allogenic cellular material (SVF) in the course of treatment of dogs suffering from degenerative joint disease in the spinal region. MATERIALS AND METHODS: The study was conducted on 10 dogs of both genders, aged between 6 and 13 years in which allogenic stromal vascular fraction of stem cells (SVF) was administered intravenously. The control group was composed of 10 clinically healthy dogs. Before treatment and after 2- and 8-week intervals blood samples were obtained from the study group dogs in order to determine VEGF levels via immunoenzymatic test. RESULTS: in a few days after the therapy, alleviation of pain symptoms and reduction of lameness were noticed. The VEGF level in 2 weeks after the therapy was significantly elevated (median: 38.77 pg/ml), while in 8 weeks a decrease was observed (median: 18.37 pg/ml). Conlusion: Administration of allogenic stem cells has a positive influence on elevation of the VEGF levels in the blood serum of affected animals as well as their regeneration capacity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31280199/