Peer-reviewed veterinary case report
Using compound 48/80 and codeine for dog skin allergy tests
By Vogelnest, L J & Mueller, R S·Published in Veterinary dermatology·2001·University Veterinary Center Camden, Australia·View original on PubMed →
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Original publication title: The use of compound 48/80 and codeine phosphate as positive controls for intradermal skin testing in dogs.
- Species:
- dog
Plain-English summary
A group of dogs suspected of having allergies underwent skin testing to check for reactions to different substances. Researchers tested a compound called compound 48/80 and codeine phosphate against histamine, a common allergen, to see how well they worked as controls. While compound 48/80 showed strong reactions in most atopic (allergy-prone) dogs, it was not a reliable indicator for all dogs. This means that while it might help identify allergies in some cases, it shouldn't be solely relied upon for testing.
People also search for: dog skin allergy testing · compound 48/80 for dog allergies · histamine skin test dogs
Abstract
The mast cell secretagogues compound 48/80 and codeine phosphate were evaluated as potential positive controls for intradermal skin testing in dogs. Wheal responses to both agents were compared with responses to histamine and saline in 11 normal dogs, and were strong and not significantly different from histamine responses in nine dogs (P < 0.01), and significantly weaker than histamine in two dogs (P < 0.05). Wheal responses to compound 48/80 (1 mg mL-1) were evaluated in 82 suspected atopic dogs and were similar to histamine in 79 dogs and markedly weaker than histamine in three dogs. Of nine confirmed atopic dogs with weak responses to injected allergens, seven had strong responses to compound 48/80, and eight had strong responses to histamine. Compound 48/80 and codeine phosphate appear unreliable positive controls for skin testing in normal dogs. Compound 48/80 (1 mg mL-1) may be a reliable positive control in atopic dogs but is a poor indicator of skin reactivity to allergens.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11360343/