Peer-reviewed veterinary case report
Cyclosporine-A treatment for chronic knee arthritis in dogs
By de Mello Souza, C H et al.·Published in Veterinary and comparative orthopaedics and traumatology : V.C.O.T·2011·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: The use of cyclosporine-A in dogs with chronic osteoarthritis: a pilot study.
- Species:
- dog
Plain-English summary
Ten hound-type dogs with chronic osteoarthritis in their knees were given a medication called cyclosporine-A for a month to see if it would help reduce their limping. Unfortunately, the treatment did not improve their lameness, as measured by their ability to put weight on their legs. After switching the treatment between the groups, the results remained the same, indicating that cyclosporine-A was not effective for these dogs.
People also search for: dog limping treatment · osteoarthritis in dogs · cyclosporine for dog arthritis
Abstract
OBJECTIVE: To evaluate the efficacy of cyclosporine-A in dogs with radiographic and physical evidence of chronic stifle osteoarthritis. MATERIALS AND METHODS: Ten hound-type dogs with osteoarthritis induced by surgical transection of a cranial cruciate ligament followed by immediate stabilization of the stifle four years prior to study start were randomized to two groups. Cyclosporine-A was administered orally once daily at 5 mg/kg to one group for one month while the other group served as control. After a two week wash-out period during which the animals were not treated, and the degree of lameness was allowed to return to baseline, the treatments were switched so that the second group received treatment with cyclosporine-A and the first group served as control. Ground reaction forces were measured using a force platform in all animals at day zero and then every two weeks until the end of the study. RESULTS: Cyclosporine-A did not alter the degree of lameness based on assessment of ground reaction forces. CONCLUSIONS: At a dose of 5 mg/kg/day for 28 days, cyclosporine-A was not effective in decreasing lameness of dogs with chronic osteoarthritis induced by surgical transection of the cranial cruciate ligament.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21597647/