Peer-reviewed veterinary case report
The Use of L-sIDOL Transgenic Mice as a Murine Model to Study Hypercholesterolemia and Atherosclerosis.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2017
- Authors:
- Zerenturk, Eser J & Calkin, Anna C
- Affiliation:
- Baker IDI Heart and Diabetes Institute · Australia
- Species:
- rodent
Abstract
There are many advantages to the use of mice as a model to study the regulation of cholesterol metabolism. Common models of hypercholesterolemia include low-density lipoprotein receptor deficient (LDLR -/-) mice and apolipoprotein E deficient (ApoE) -/- mice. Herein, we describe the recently generated mouse model, L-sIDOL Tg mice, which express a dominant active form of Inducible Degrader Of the Low-density lipoprotein receptor (IDOL) in a liver-specific manner. This murine model offers significant advantages over previously established models for the study of hypercholesterolemia and atherosclerosis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28205167/