Peer-reviewed veterinary case report
Plasma exchange treatment for acute nerve disease in one dog
By Greenfield, Z P et al.·Published in The Journal of small animal practice·2025·Internal Medicine Service, United States·View original on PubMed →
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Original publication title: The use of membrane-based therapeutic plasma exchange for the management of acute canine polyradiculoneuritis and reduction of antigen-specific IgG in one dog.
- Species:
- dog
Plain-English summary
A 5-year-old female mixed-breed dog was diagnosed with acute canine polyradiculoneuritis, a condition that affects the nerves and can cause weakness and difficulty moving. She underwent a new treatment called membrane-based therapeutic plasma exchange, which helped reduce specific antibodies in her blood that were linked to her condition. Remarkably, she showed improvement in her ability to move just 48 hours after the first treatment and made a full recovery within a month.
People also search for: dog weakness treatment · canine polyradiculoneuritis symptoms · plasma exchange for dogs
Abstract
Acute canine polyradiculoneuritis is one of the most common lower motor neuron diseases in dogs. Given similarities to Guillain-Barré syndrome in people, an immune-mediated component has long been suspected. In veterinary medicine, two studies have documented specific antibodies as serum biomarkers for acute canine polyradiculoneuritis, including anti-GM2 and anti-GalNAc-GD1a immunoglobulin G anti-glycolipid antibodies. This case report documents the first use of membrane-based therapeutic plasma exchange for the management of acute canine polyradiculoneuritis as well as an overall reduction in anti-GM2 IgG and anti-GalNAc-GD1a IgG with subsequent treatments. The clinical recovery in this dog was rapid, with improved motor function within 48 hours of her first treatment and a complete return to normal within 1 month.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40468564/