Peer-reviewed veterinary case report
BAX protein levels predict survival in dogs with skin mast cell tumors
By Strefezzi, R De F et al.·Published in Journal of comparative pathology·2012·Faculdade de Zootecnia e Engenharia de Alimentos, Brazil·View original on PubMed →
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Original publication title: The value of immunohistochemical expression of BAX in formulating a prognosis for canine cutaneous mast cell tumours.
- Species:
- dog
Plain-English summary
A study looked at 24 dogs with skin tumors called mast cell tumors to see how a protein called BAX could help predict their outcome. It found that dogs with higher levels of BAX were much more likely to have a worse prognosis, meaning they had a higher chance of dying from the disease and shorter survival times after surgery. This suggests that checking BAX levels could help veterinarians understand how aggressive the tumors are and what the likely outcome might be for the dog.
People also search for: dog mast cell tumor prognosis · BAX protein in dogs · canine skin tumor survival rates
Abstract
Immunohistochemical expression of BAX was evaluated in 24 canine cutaneous mast cell tumours in order to verify the relationship of this expression to the histopathological grade of the lesions and its prognostic value for clinical outcome. BAX expression increased with higher histopathological grades (P=0.0148; P<0.05 between grades I and III). Animals with high levels of BAX expression were 4.25 times more likely to die from the disease and had shorter post-surgical survival times (P=0.0009). These results suggest that alterations in BAX expression may be related to the aggressiveness of canine cutaneous mast cell tumours, indicating that immunohistochemical detection of BAX may be predictive of clinical outcome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21899858/