Peer-reviewed veterinary case report
KIT gene expression does not predict recurrence or death in dog skin
By Costa Casagrande, T A et al.·Published in Veterinary and comparative oncology·2015·Positivo University, Brazil·View original on PubMed →
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Original publication title: The value of molecular expression of KIT and KIT ligand analysed using real-time polymerase chain reaction and immunohistochemistry as a prognostic indicator for canine cutaneous mast cell tumours.
- Species:
- dog
Plain-English summary
A study looked at dogs with mast cell tumors, a type of skin cancer, to see if certain gene expressions could predict how likely the tumors were to come back or cause death. Researchers found that while different patterns of a gene called KIT were observed in the tumors, these patterns did not significantly relate to the dogs' survival or recurrence rates. However, they noted that unusual KIT localization might indicate more aggressive tumor behavior. Overall, while the KIT gene expression can be measured, it doesn't seem to help predict outcomes for dogs with mast cell tumors.
People also search for: dog mast cell tumor prognosis · canine skin cancer treatment · mast cell tumor recurrence in dogs
Abstract
This study investigated the correlation between KIT gene expression determined by immunohistochemistry and real-time polymerase chain reaction (RT-PCR) and the rate of tumour recurrence and tumour-related deaths in dogs affected with mast cell tumour (MCT). Kaplan-Meier curves were constructed to compare tumour recurrence and tumour-related death between patients. The log-rank test was used to check for significant differences between curves. KIT-I, KIT-II and KIT-III staining patterns were observed in 9 (11.11%), 50 (61.73%) and 22 (27.16%) tumours, respectively. Tumour recurrence rates and tumour-related deaths were not associated with KIT staining patterns (P = 0278, P > 0.05), KIT (P = 0.289, P > 0.05) or KIT ligand (P = 0.106, P > 0.05) gene expression. Despite the lack of association between KIT staining pattern and patient survival time, the results suggest a correlation between aberrant KIT localization and increased proliferative activity of MCTs. RT-PCR seems to be a sensible method for quantitative detection of KIT gene expression in canine MCT, although expressions levels are not correlated with prognosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23294979/