Peer-reviewed veterinary case report
How acidemia affects blood clotting in dogs and its reversal
By Kim, Youngju et al.·Published in Frontiers in veterinary science·2024·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Theeffects of acidemia and acidemia reversal on coagulation in dogs.
- Species:
- dog
Plain-English summary
A study found that strong acidemia (a condition where the blood becomes too acidic) in six healthy Beagle dogs led to problems with blood clotting. Tests showed that the dogs had longer clotting times and other issues with their blood's ability to form clots. However, when the acid levels were corrected, most of these clotting problems improved significantly. This suggests that treating acidemia can help restore normal blood coagulation in dogs.
People also search for: dog blood clotting problems · Beagle acidemia treatment · dog coagulation issues
Abstract
BACKGROUND: The effect of acidemia on blood coagulation remains inadequately understood in veterinary medicine. Therefore, we assessed the effect ofacidification of canine whole blood on coagulation and investigated whether acidemia-induced coagulopathy could be reversed by reversing acidemia. METHODS: Citrated whole blood samples were taken from six healthy Beagle dogs and categorized, based on pH adjustment, into neutral, weak acidemia (WA), strong acidemia (SA), and reversal from SA. Then, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen concentration, conventional thromboelastography (TEG) parameters, and velocity curve (V-curve) variables of TEG were assessed. RESULTS: The PT, aPTT, and most TEG parameters showed significant coagulopathy in the SA group compared to the neutral group, with additional significant changes in reaction time (R), clot kinetic (K), maximum amplitude (MA), split point (SP), elasticity (E), thrombodynamic potential index (TPI), and coagulation index (CI) between the SA and WA groups. Among V-curve variables, the maximum rate of thrombus generation (MRTG) and total thrombus generation were significantly inhibited in the SA group compared to the neutral group, with significant differences in the time to maximum rate of thrombus generation (TMRTG) between the WA and SA groups. In the reverse group, aPTT, R, K, α-angle, MRTG, TMRTG, SP, TPI, and CI exhibited significant recovery compared to the SA group. CONCLUSION: Theinduction of acidemia in canine whole blood leads to impairment of coagulation profiles, and pH correction can reverse most acidemia-induced coagulopathy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39301280/