Peer-reviewed veterinary case report
Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2016
- Authors:
- Kanai, Kazutaka et al.
- Affiliation:
- Department of Small Animal Internal Medicine I · Japan
- Species:
- rodent
Abstract
The present study aimed to investigate the therapeutic efficacy of post-inflammatory treatment with luteolin on endotoxin-induced uveitis (EIU) in rats. Intraperitoneal injection of 10 mg/kg luteolin or 1 mg/kg prednisolone (Pred) at 4 hr post-lipopolysaccharide (LPS) injection (200 µg) was associated at 24 hr post-LPS injection with decreased clinical severity scores, number of inflammatory cells, protein levels and levels of tumor necrosis factor (TNF)-α, nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor (AqH) and degrees of histological ocular tissue injury. The anti-inflammatory potency of luteolin was comparable to that of Pred. Luteolin exhibited robust efficacy in the treatment of EIU in rats, indicating its potential clinical utility in treating uveitis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27170432/