Peer-reviewed veterinary case report
NT-proBNP blood levels drop after surgery in dogs with patent ductus
By Aramaki, Yoshitaka et al.Ā·Published in The Journal of veterinary medical scienceĀ·2011Ā·Chimura Veterinary Hospital, JapanĀ·View original on PubMed ā
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Original publication title: Therapeutic changes of plasma N-terminal pro-brain natriuretic peptide concentrations in 9 dogs with patent ductus arteriosus.
- Species:
- dog
Plain-English summary
A 5-year-old female mixed-breed dog was diagnosed with a heart condition called patent ductus arteriosus (PDA), which can lead to heart failure. After surgery to correct this condition, the dog's heart function was closely monitored using a blood test that measures a substance called NT-proBNP, which indicates heart stress. The results showed that the dog's heart condition improved significantly after surgery, with lower NT-proBNP levels and better overall heart health. This suggests that measuring NT-proBNP can help vets assess how well treatments for heart problems are working.
People also search for: dog heart murmur treatment Ā· patent ductus arteriosus surgery for dogs Ā· NT-proBNP levels in dogs
Abstract
The plasma N-terminal proBNP (NT-proBNP) concentration is measured for determining the diagnosis and severity of heart failure in dogs. However, it is still unclear whether measurements of circulating NT-proBNP levels provide clinical utility as an indicator of therapeutic efficacy. Thus, we investigated the surgical correction-related changes of plasma NT-proBNP concentrations in 9 dogs with patent ductus arteriosus (PDA). Physical examination, thoracic radiography and echocardiography were conducted both before and after surgery. Similarly, the plasma NT-proBNP concentrations were determined using an enzyme immunoassay for canine pro-BNP. The International Small Animal Cardiac Health Council (ISACHC) class and murmur grade were significantly improved after surgery compared with before surgery. Vertebral heart size (VHS) and cardiothoracic ratio (CTR) were significantly decreased after surgery. Fractional shortening was significantly decreased and relative wall thickness (RWT) was significantly increased after surgery. Furthermore, the plasma NT-proBNP concentrations were significantly decreased by surgical correction. The plasma NT-proBNP concentration showed significant positive correlation with the ISACHC class, murmur grade, VHS and CTR and significant negative correlation with the RWT. Therefore, measurement of plasma NT-proBNP levels can be used to monitor the effectiveness of therapies such as surgical correction of PDA.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20823663/