Peer-reviewed veterinary case report
Monitoring itraconazole levels in dogs treated for blastomycosis
By Reinhart, Jennifer M et al.·Published in Journal of veterinary internal medicine·2026·Department of Veterinary Clinical Medicine, United States·View original on PubMed →
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Original publication title: Therapeutic drug monitoring of itraconazole in treatment of blastomycosis in dogs.
- Species:
- dog
Plain-English summary
Fourteen dogs with blastomycosis, a serious fungal infection, were treated with itraconazole, a common antifungal medication. After starting with a dose of 5 mg/kg/day, the veterinarians monitored the dogs' blood levels of the drug to ensure they stayed within a safe range. Most dogs needed their dosages adjusted multiple times during treatment, which lasted about 8 months on average. Ultimately, all the dogs achieved remission from the infection, but the amount of itraconazole needed decreased over time.
People also search for: dog blastomycosis treatment · itraconazole dosage for dogs · how to monitor itraconazole levels in dogs
Abstract
BACKGROUND: Itraconazole is a widely used treatment for blastomycosis in dogs but serum drug concentrations vary widely between individuals. HYPOTHESIS/OBJECTIVES: Establish a protocol for therapeutic drug monitoring of itraconazole in dogs with blastomycosis. ANIMALS: Fourteen dogs with blastomycosis. METHODS: Single-arm, prospective study. The initial dosage of itraconazole was 5 mg/kg/day. Therapeutic drug monitoring was performed after 2 weeks and then monthly until clinical and antigenic remission. Itraconazole dosages were adjusted to maintain trough serum concentrations within the target range (2-7 μg/mL) using a standardized equation. RESULTS: Twelve of 14 dogs required at least 1 dosage adjustment and 9 dogs required additional adjustments even after target concentrations were initially achieved. Dosage changes tended to occur at sequential visits, often consisting of a dosage increase followed by a dosage decrease at the next visit, or vice versa. No correlation was found between itraconazole dosage and serum concentration (r = 0.080, P = .43). Dogs were treated for a median of 7.9 months (range, 2.6-9.9). Median itraconazole dosage at disease remission (2.8 mg/kg/day; range, 0.9-5.0) was significantly lower than the initial dosage (4.9 mg/kg/day; range, 4.0-5.4; P < .001). All dogs successfully achieved remission of blastomycosis and only one occurrence of antigenic relapse occurred. CONCLUSIONS AND CLINICAL IMPORTANCE: Most dogs with blastomycosis require dosage adjustments to maintain itraconazole concentrations in the target range. Repeat serum drug concentrations should be measured after dosage adjustments to ensure target concentrations are reached. Although 5 mg/kg/day is an appropriate initial dosage, the itraconazole dosage needed to maintain target serum concentrations appears to decrease over time.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41742595/